发明授权
- 专利标题: Benzyl piperidine compound
- 专利标题(中): 苄基哌啶化合物
-
申请号: US13388623申请日: 2010-08-04
-
公开(公告)号: US08778970B2公开(公告)日: 2014-07-15
- 发明人: Tomohiro Toyoda , Tomoaki Nishida , Hidefumi Yoshinaga
- 申请人: Tomohiro Toyoda , Tomoaki Nishida , Hidefumi Yoshinaga
- 申请人地址: JP Osaka
- 专利权人: Dainippon Sumitomo Pharma Co., Ltd
- 当前专利权人: Dainippon Sumitomo Pharma Co., Ltd
- 当前专利权人地址: JP Osaka
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2009-181550 20090804
- 国际申请: PCT/JP2010/063148 WO 20100804
- 国际公布: WO2011/016468 WO 20110210
- 主分类号: A61K31/453
- IPC分类号: A61K31/453 ; C07D405/10
摘要:
Provided is a new serotonin-reuptake inhibitor that exhibits affinity for serotonin-1A receptors. Said serotonin-reuptake inhibitor is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. In the formula, R1 represents a hydrogen atom, a 2-hydroxyethyl group, or a 2-methoxyethyl group. R2 represents one of the following bonded to a methylene group which is bonded to a piperidine ring: a chlorine atom bonded in a p-position; a bromine atom bonded in a p-position; a methyl group bonded in a p-position; a chlorine atom bonded in an m-position; or a bromine atom bonded in an m-position. Either Y1 represents a hydrogen atom and Y2 represents a hydrogen atom or a hydroxyl group, or Y1 and Y2 together represent an oxo group. Z represents a group represented by one of the following formulas: formula (3-1-1), formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2). However, if R1 represents a 2-hydroxyethyl group or a 2-methoxyethyl group and Y1 and Y2 both simultaneously represent hydrogen atoms, then Z represents a group represented by one of the following formulas: formula (3-1-2), formula (3-2-1), formula (3-2-2), formula (3-3-1), formula (3-3-2), formula (3-4-1), or formula (3-4-2).
公开/授权文献
- US20120130077A1 BENZYL PIPERIDINE COMPOUND 公开/授权日:2012-05-24
信息查询
IPC分类: