发明授权
- 专利标题： Stabilized and lyophilized formulation of anthracycline compounds
- 专利标题（中）： 蒽环类化合物的稳定和冻干制剂
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申请号： US13322151申请日： 2009-05-27
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公开(公告)号： US08785406B2公开(公告)日： 2014-07-22
- 发明人: Hajimu Hirofuji , Hotaka Hashimoto , Kazunari Tanaka
- 申请人： Hajimu Hirofuji , Hotaka Hashimoto , Kazunari Tanaka
- 申请人地址： JP Osaka
- 专利权人： Dainippon Sumitomo Pharma Co., Ltd.
- 当前专利权人： Dainippon Sumitomo Pharma Co., Ltd.
- 当前专利权人地址： JP Osaka
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 国际申请： PCT/JP2009/059682 WO 20090527
- 国际公布： WO2010/137131 WO 20101202
- 主分类号： A61K31/70
- IPC分类号： A61K31/70
摘要：
The present invention provides a lyophilized amrubicin formulation and a process thereof. In the process, the concentration of the aqueous solution before lyophilization is controlled to about 7.5 mg(potency)/mL or more. Thus, the formulation decreases the production of desaccharified compound and is stable to storage for a long period. The formulation is useful as a cancer chemotherapeutic agent.
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