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Invention Grant
US08785488B2 Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity 有权
用作治疗糖尿病和肥胖症的TGR5激动剂的三唑和咪唑衍生物

Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity
Abstract:
The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated.
Abstract(Chinese):

本发明包括结构式I的TGR5激动剂，其中X，R 1，R 2和R 5在本文中定义，以及它们的N-氧化物及其药学上可接受的盐。 本发明还包括包含化合物，N-氧化物和/或其药学上可接受的盐的组合物。 本发明还包括使用化合物和组合物来治疗其中TGR5是介质或涉及的疾病。 本发明还包括在药物中和用于制备药物中的用途，特别是用于治疗其中TGR5是介质或涉及的疾病。

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