A display device includes a substrate, a backplane, a display medium layer, a protective layer, a driving component, a flexible printed circuit (FPC) and a sealant. The backplane and the display medium layer are disposed on the lower side and the upper side of the substrate, respectively. The protective layer covers the display medium layer and prevents moisture and oxygen from permeating into the display medium layer to deteriorate its performance. The sealant surrounds the first side surface of the substrate and the second side surface of the display medium layer, and wraps at least a portion of the driving component and a portion of the FPC. Additionally, a manufacturing method of a display device is also provided.