In accordance with an embodiment, there is provided a method comprising receiving, at a receiver, a desired signal and an interfering signal, wherein the interfering signal was transmitted with a modulation unknown to the receiver; identifying a likely modulation corresponding to the modulation with which the interfering signal was transmitted; and decoding the desired signal using a modulation dependent multiple-input multiple output (MIMO) detection, wherein the modulation dependent MIMO detection is based at least in part on the identified likely modulation corresponding to the modulation with which the interfering signal was transmitted, wherein the modulation dependent MIMO detection includes maximum likelihood (ML) detection.