发明授权
- 专利标题: Dihydropyrazolopyrimidinone derivatives
- 专利标题(中): 二氢吡唑并嘧啶酮衍生物
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申请号: US13053798申请日: 2011-03-22
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公开(公告)号: US08791125B2公开(公告)日: 2014-07-29
- 发明人: Takeshi Sagara , Sachie Otsuki , Satoshi Sunami , Toshihiro Sakamoto , Kenji Niiyama , Fuyuki Yamamoto , Takashi Yoshizumi , Hidetomo Furuyama , Yasuhiro Goto , Makoto Bamba , Keiji Takahashi , Hiroshi Hirai , Toshihide Nishibata
- 申请人: Takeshi Sagara , Sachie Otsuki , Satoshi Sunami , Toshihiro Sakamoto , Kenji Niiyama , Fuyuki Yamamoto , Takashi Yoshizumi , Hidetomo Furuyama , Yasuhiro Goto , Makoto Bamba , Keiji Takahashi , Hiroshi Hirai , Toshihide Nishibata
- 申请人地址: JP Chiyoda-Ku, Tokyo
- 专利权人: MSD K.K.
- 当前专利权人: MSD K.K.
- 当前专利权人地址: JP Chiyoda-Ku, Tokyo
- 代理商 Yong Zhao; Laura M. Ginkel; Joan E. Switzer
- 优先权: JP2006/124208 20060427
- 主分类号: A01N43/90
- IPC分类号: A01N43/90 ; A61K31/519 ; C07D487/00
摘要:
The invention relates to compounds of a general formula (I): wherein Ar1 is an optionally-substituted aryl or heteroaromatic group; R1 is an optionally-substituted lower alkyl, lower alkenyl, lower alkynyl or cyclo-lower alkyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R2 is a hydrogen atom, a lower alkyl group, a lower alkenyl group or a lower alkynyl group, or is an aryl, aralkyl or heteroaromatic group optionally having a substituent; R3 is a hydrogen atom or a lower alkyl group; R4 is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group or a group of —N(R1k)R1m; T and U are a nitrogen atom or a methine group, etc. The compounds of the invention have excellent Weel kinase-inhibitory effect and are therefore useful in the field of medicines, especially treatment of various cancers.
公开/授权文献
- US20110189130A1 DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVES 公开/授权日:2011-08-04