An equalization device is arranged for equalizing a received signal, wherein the received signal may include a primary signal and at least one interference signal. The equalization device may include a transformation module, a serial-to-parallel converter, and an equalization module, wherein the transformation module may include a predictive decision feed-back equalizer, a first feed-back filter and an adder. The transformation module is arranged for generating a transformation signal according to the primary signal and the at least one interference signal of the received signal, wherein the transformation signal includes a transformed primary signal and at least one transformed interference signal. The serial-to-parallel converter is arranged for respectively converting the transformed primary signal and the transformed interference signal into a plurality of transformation signal sequences. The equalization module is arranged for respectively equalizing the plurality of transformation signal sequences so as to generate a plurality of equalized sequences.