发明授权
US08795654B2 Methods for improving the tissue penetration of a drug by administering the drug together with a hyaluronidase protein
有权
通过将药物与透明质酸酶蛋白一起施用来改善药物组织穿透的方法
- 专利标题： Methods for improving the tissue penetration of a drug by administering the drug together with a hyaluronidase protein
- 专利标题（中）： 通过将药物与透明质酸酶蛋白一起施用来改善药物组织穿透的方法
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申请号： US13620470申请日： 2012-09-14
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公开(公告)号： US08795654B2公开(公告)日： 2014-08-05
- 发明人: Tamara P. Uvarkina , Eugene G. Kahojan
- 申请人： Tamara P. Uvarkina , Eugene G. Kahojan
- 代理机构： Fish & Richardson P.C.
- 主分类号： A61K38/46
- IPC分类号： A61K38/46 ; C12N9/00 ; C12N9/10 ; C12N1/20 ; C12N15/00 ; C07H21/04
摘要：
The present invention provides a tnaluronidase. The hyaiuronidase can be produced by the strain Streptomyces aitinocidm 77, Exemplary characteristics of the hyaluronidase include specific C-terminal or other amino acid sequences, including full-length sequences, and improved physico-chemical and actix itj properties as compared to known h>aluronidase preparatkiiis. Described are also various uses of the hyaiuronidase, including topical administration of the h>aiuronidase to improve skin penetration of a co-administered active substance.
公开/授权文献
- US20130189242A1 Hyaluronidase and Method of use Thereof 公开/授权日：2013-07-25
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