Invention Grant
- Patent Title: Production of glycoproteins with reduced O-glycosylation
- Patent Title (中): 生产具有降低的O-糖基化的糖蛋白
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Application No.: US13530768Application Date: 2012-06-22
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Publication No.: US08795984B2Publication Date: 2014-08-05
- Inventor: Piotr Bobrowicz , W. James Cook , Warren Kett
- Applicant: Piotr Bobrowicz , W. James Cook , Warren Kett
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Immac J. Thampoe; John David Reilly
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12N1/15 ; C12N1/19 ; A01N43/78 ; C07D277/26
Abstract:
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.
Public/Granted literature
- US20120322101A1 PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION Public/Granted day:2012-12-20
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