发明授权
- 专利标题： Production of glycoproteins with reduced O-glycosylation
- 专利标题（中）： 生产具有降低的O-糖基化的糖蛋白
-
申请号： US13530768申请日： 2012-06-22
-
公开(公告)号： US08795984B2公开(公告)日： 2014-08-05
- 发明人: Piotr Bobrowicz , W. James Cook , Warren Kett
- 申请人： Piotr Bobrowicz , W. James Cook , Warren Kett
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Immac J. Thampoe; John David Reilly
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; C12N1/15 ; C12N1/19 ; A01N43/78 ; C07D277/26
摘要：
A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.
公开/授权文献
- US20120322101A1 PRODUCTION OF GLYCOPROTEINS WITH REDUCED O-GLYCOSYLATION 公开/授权日：2012-12-20
信息查询
