Invention Grant
- Patent Title: Tricyclic imidazole compounds as PDE10 inhibitors
- Patent Title (中): 三环咪唑化合物作为PDE10抑制剂
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Application No.: US14016685Application Date: 2013-09-03
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Publication No.: US08796304B2Publication Date: 2014-08-05
- Inventor: Jan Kehler , Jacob Nielsen , Mauro Marigo , John Paul Kilburn , Morten Langgård
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agent Mary Catherine Di Nunzio
- Main IPC: A61K31/437
- IPC: A61K31/437 ; C07D471/06 ; C07D487/06
Abstract:
The invention is directed to compounds with the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
Public/Granted literature
- US20140005201A1 Tricyclic imidazole compounds as PDE10 inhibitors Public/Granted day:2014-01-02
Information query
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