Disclosed is a method for a serving base station in a wireless communication system to mitigate inter-cell interference. More specifically, the method comprises the steps of: allocating a first resource for a terminal existing in a first region in which the coverage of the serving base station and the coverage of a neighboring base station are overlapped with each other; and allocating a second resource with the first resource for a terminal existing in a second region of the coverage of the serving base station, which is outside of the coverage of the neighboring base station. Desirably, the first resource is for the serving base station only with reuse factor of ½, and the second resource is shared with the neighboring base station with reuse factor of 1.