Invention Grant
- Patent Title: Labeling agent and methods for simultaneous sequencing and quantification of multiple peptides and proteins using the same
- Patent Title (中): 用于同时测序和定量多种肽和蛋白质的标记试剂和方法
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Application No.: US13818489Application Date: 2011-08-23
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Publication No.: US08809012B2Publication Date: 2014-08-19
- Inventor: Seung Koo Shin , Hye Joo Yoon , Yong Sik Jung , Hee Yoon Lee , Min Soo Suh , Jong Cheol Seo
- Applicant: Seung Koo Shin , Hye Joo Yoon , Yong Sik Jung , Hee Yoon Lee , Min Soo Suh , Jong Cheol Seo
- Applicant Address: KR Gyeongsangbuk-do
- Assignee: Postach Academy-Industry Foundation
- Current Assignee: Postach Academy-Industry Foundation
- Current Assignee Address: KR Gyeongsangbuk-do
- Agency: Brinks Gilson & Lione
- Priority: KR10-2010-0081659 20100823; KR10-2010-0100538 20101014
- International Application: PCT/KR2011/006225 WO 20110823
- International Announcement: WO2012/026743 WO 20120301
- Main IPC: C12Q1/37
- IPC: C12Q1/37 ; C07C237/12 ; C07C237/20
Abstract:
The present invention provides a compound that can utilize hydrogen isotope and, at the same time, can quantify multiplexed samples at one time, as well as decreasing the cost for synthesis of the labeling agent. In addition, the present invention provides a novel method for quantitatively analyzing protein and peptide analytes having different quantities form each other using the labeling agent, wherein y-type fragment ions having a high mass which comprises the analyte remained after coupling the labeling agent with the analyte and then removing a part of the labeling agent through tandem mass spectrometry are utilized to conduct the quantitative analysis.
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