发明授权
US08809051B2 Transgenic mammals having human Ig loci including plural VH and Vκ regions and antibodies produced therefrom
有权
具有人Ig位点的转基因哺乳动物包括多个VH和V＆Kgr; 区域和抗体
- 专利标题： Transgenic mammals having human Ig loci including plural VH and Vκ regions and antibodies produced therefrom
- 专利标题（中）： 具有人Ig位点的转基因哺乳动物包括多个VH和V＆Kgr; 区域和抗体
-
申请号： US11894779申请日： 2007-08-20
-
公开(公告)号： US08809051B2公开(公告)日： 2014-08-19
- 发明人: Aya Jakobovits , Raju Kucherlapati , Susan Klapholz , Michael J Mendez , Larry Green
- 申请人： Aya Jakobovits , Raju Kucherlapati , Susan Klapholz , Michael J Mendez , Larry Green
- 申请人地址： US CA South San Francisco
- 专利权人： Amgen Fremont Inc.
- 当前专利权人： Amgen Fremont Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Ropes & Gray LLP
- 代理商 Jane T. Gunnison; Raymond M. Doss
- 主分类号： C12N5/0735
- IPC分类号： C12N5/0735 ; C12N5/0781 ; C12N5/10 ; A01K67/027
摘要：
The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.