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发明授权
US08809359B2 Phenyl amino pyrimidine bicyclic compounds and uses thereof 有权
苯基氨基嘧啶双环化合物及其用途

Phenyl amino pyrimidine bicyclic compounds and uses thereof
摘要：
The present invention relates to phenyl amino pyrimidine bicyclic compounds formula I which are inhibitors of protein kinases including JAK kinases. In particular the compounds are active against JAK1, JAK2, JAK3 and TYK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.
摘要（中）：

本发明涉及作为蛋白激酶（包括JAK激酶）的抑制剂的苯基氨基嘧啶双环化合物式I。 特别地，这些化合物对JAK1，JAK2，JAK3和TYK2激酶具有活性。 激酶抑制剂可用于治疗激酶相关疾病，例如免疫学和炎性疾病，包括器官移植物; 过度增生性疾病，包括癌症和骨髓增生性疾病; 病毒性疾病 代谢疾病; 和血管疾病。

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