发明授权
- 专利标题: Microelectronic sensor device for DNA detection
- 专利标题(中): 用于DNA检测的微电子传感器装置
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申请号: US12303448申请日: 2007-05-24
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公开(公告)号: US08815162B2公开(公告)日: 2014-08-26
- 发明人: Erik Robbert Vossenaar , Marc Wilhelmus Gijsbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
- 申请人: Erik Robbert Vossenaar , Marc Wilhelmus Gijsbert Ponjee , Hendrik Roelof Stapert , Mark Thomas Johnson
- 申请人地址: NL Eindhoven
- 专利权人: Koninklijke Philips N.V.
- 当前专利权人: Koninklijke Philips N.V.
- 当前专利权人地址: NL Eindhoven
- 优先权: EP06115176 20060608
- 国际申请: PCT/IB2007/051960 WO 20070524
- 国际公布: WO2007/141700 WO 20071213
- 主分类号: G05D23/00
- IPC分类号: G05D23/00
摘要:
The invention relates to a microelectronic sensor device and a method for the investigation of biological target substances (20), for example oligonucleotides like DNA fragments. In one embodiment, the device comprises a reaction surface (RS) to which target specific reactants (10) are attached and which lies between a sample chamber (SC) and an array of selectively controllable heating elements (HE). The temperature profile in the sample chamber (SC) can be controlled as desired to provide for example conditions for a PCR and/or for a controlled melting of hybridizations. The reactant (10) and/or the target substance (20) comprises a label (12) with an observable property, like fluorescence, that changes if the target substance (20) is bound to the reactant (10), said property being detected by an array of sensor elements, for example photosensors (SE). The fluorescence of the label (12) may preferably be transferred by FRET to a different fluorescent label (22) or quenched if the target substance (20) is bound.
公开/授权文献
- US20090325164A1 MICROELECTRONIC SENSOR DEVICE FOR DNA DETECTION 公开/授权日:2009-12-31
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