发明授权
- 专利标题: Aglycosylated immunoglobulin mutants
- 专利标题(中): 糖基化免疫球蛋白突变体
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申请号: US12746411申请日: 2008-12-05
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公开(公告)号: US08815237B2公开(公告)日: 2014-08-26
- 发明人: K. Dane Wittrup , Jeffrey Ravetch , Stephen Lael Sazinsky
- 申请人: K. Dane Wittrup , Jeffrey Ravetch , Stephen Lael Sazinsky
- 申请人地址: US MA Cambridge US NY New York
- 专利权人: Massachusetts Institute of Technology,The Rockefeller University
- 当前专利权人: Massachusetts Institute of Technology,The Rockefeller University
- 当前专利权人地址: US MA Cambridge US NY New York
- 代理机构: Hamilton, Brook, Smith & Reynolds, P.C.
- 国际申请: PCT/US2008/085757 WO 20081205
- 国际公布: WO2009/079242 WO 20090625
- 主分类号: A61K39/395
- IPC分类号: A61K39/395
摘要:
The present invention is based, in part, on our discovery of immunoglobulins (e.g., immunoglobulin G (IgG)) polypeptides (e.g., murine or human IgG, such as human IgG1) that are aglycosylated yet retain the ability to bind to an Fc receptor, such as an activating Fc receptor (e.g., FcγRIIA and/or FcγRIIIA).
公开/授权文献
- US20110059075A1 AGLYCOSYLATED IMMUNOGLOBULIN MUTANTS 公开/授权日:2011-03-10
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