发明授权
- 专利标题： Tricyclic derivative or pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition containing the same
- 专利标题（中）： 三环衍生物或其药学上可接受的盐，其制备方法和含有它们的药物组合物
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申请号： US13128030申请日： 2009-11-11
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公开(公告)号： US08815891B2公开(公告)日： 2014-08-26
- 发明人: Myung-Hwa Kim , Seung-Hyun Kim , Sae-Kwang Ku , Chun-Ho Park , Bo-Young Joe , Kwang-Woo Chun , In-Hae Ye , Jong-Hee Choi , Dong-Kyu Ryu , Ji-Seon Park , Han-Chang Lee , Ji-So Choi , Young-Chul Kim
- 申请人： Myung-Hwa Kim , Seung-Hyun Kim , Sae-Kwang Ku , Chun-Ho Park , Bo-Young Joe , Kwang-Woo Chun , In-Hae Ye , Jong-Hee Choi , Dong-Kyu Ryu , Ji-Seon Park , Han-Chang Lee , Ji-So Choi , Young-Chul Kim
- 申请人地址： KR Seoul
- 专利权人： Je Il Pharmaceutical Co., Ltd.
- 当前专利权人： Je Il Pharmaceutical Co., Ltd.
- 当前专利权人地址： KR Seoul
- 代理机构： Lucas & Mercanti, LLP
- 优先权： KR10-2008-0111808 20081111
- 国际申请： PCT/KR2009/006618 WO 20091111
- 国际公布： WO2010/056038 WO 20100520
- 主分类号： C07D471/06
- IPC分类号： C07D471/06 ; A61K31/4375
摘要：
The present invention relates to a novel tricyclic derivative with efficient inhibitory activity against poly(ADP-ribose)polymerases (PARP) or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition containing the same. The tricyclic derivative of the invention is useful for the prevention or treatment of diseases caused by excess PARP activity, especially neuropathic pain, neurodegenerative diseases, cardiovascular diseases, diabetic nephropathy, inflammatory diseases, osteoporosis, and cancer, by inhibiting the activity of poly(ADP-ribose)polymerases.
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