发明授权
- 专利标题： Indole derivative and pharmacologically acceptable salt thereof
- 专利标题（中）： 吲哚衍生物及其药理学上可接受的盐
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申请号： US13980604申请日： 2012-01-24
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公开(公告)号： US08815903B2公开(公告)日： 2014-08-26
- 发明人: Kazuya Tatani , Atsushi Kondo , Tatsuhiro Kondo , Naohiro Kawamura , Shigeki Seto , Yasushi Kohno
- 申请人： Kazuya Tatani , Atsushi Kondo , Tatsuhiro Kondo , Naohiro Kawamura , Shigeki Seto , Yasushi Kohno
- 申请人地址： JP Nagano JP Tokyo
- 专利权人： Kissei Pharmaceutical Co., Ltd.,Kyorin Pharmaceutical Co., Ltd.
- 当前专利权人： Kissei Pharmaceutical Co., Ltd.,Kyorin Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Nagano JP Tokyo
- 代理商 Richard S. Echler
- 优先权： JP2011-012955 20110125
- 国际申请： PCT/JP2012/051402 WO 20120124
- 国际公布： WO2012/102255 WO 20120802
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; A61K31/404 ; A61K31/41 ; A61K31/4245 ; A61K31/427 ; A61K31/444 ; A61K31/506 ; C07D401/06 ; C07D401/14 ; C07D405/06 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/06
摘要：
The present invention provides a compound represented by the general formula (I) of the present invention, which has EP1 receptor antagonism: wherein A represents a benzene ring, a pyridine ring, or the like; Y1 represents a C1-6 alkylene group or the like; Y2 represents a single bond or the like; Z represents —C(═O)—NHSO2R6, an acidic 5-membered hetero ring group, or the like; R1 represents a hydrogen atom or the like; R2 represents a phenyl group, a 5-membered aromatic heterocyclic group, or the like; R3 represents a halogen atom, a C1-6 alkoxy group, or the like; R4 represents a hydrogen atom, a halogen atom, or the like; R5 represents a hydrogen atom or the like; and R6 represents a C1-6 alkyl group or the like], or a pharmaceutically acceptable salt thereof. Furthermore, the compound (I) of the present invention can be used as an agent for treating or preventing LUTS, in particular, various symptoms of OABs.