发明授权
- 专利标题： Tympanic membrane permeating ear drops and uses thereof
- 专利标题（中）： 鼓膜渗透耳滴及其用途
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申请号： US12993358申请日： 2009-05-19
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公开(公告)号： US08822410B2公开(公告)日： 2014-09-02
- 发明人: Emmanuel John Simons , Todd R. Hoare , Daniel S. Kohane , Robert S. Langer
- 申请人： Emmanuel John Simons , Todd R. Hoare , Daniel S. Kohane , Robert S. Langer
- 申请人地址： US MA Boston US MA Cambridge
- 专利权人： Children's Medical Center Corporation,Massachusetts Institute of Technology
- 当前专利权人： Children's Medical Center Corporation,Massachusetts Institute of Technology
- 当前专利权人地址： US MA Boston US MA Cambridge
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 代理商 C. Hunter Baker
- 国际申请： PCT/US2009/003084 WO 20090519
- 国际公布： WO2009/142719 WO 20091126
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K31/7048 ; A61K31/18 ; A61P27/16 ; A61K8/18 ; A61K31/245 ; A61K31/42 ; A61K31/38 ; A61K47/48 ; A61K9/00
摘要：
The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
公开/授权文献
- US20110166060A1 TYMPANIC MEMBRANE PERMEATING EAR DROPS AND USES THEREOF 公开/授权日：2011-07-07
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