发明授权
US08822464B2 N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
有权
N-芳基 - 哌嗪衍生物及其作为mGluR5受体的正变构调节剂的用途
- 专利标题： N-aryl-piperazine derivatives and their use as positive allosteric modulators of mGluR5 receptors
- 专利标题（中）： N-芳基 - 哌嗪衍生物及其作为mGluR5受体的正变构调节剂的用途
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申请号： US13684606申请日： 2012-11-26
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公开(公告)号： US08822464B2公开(公告)日： 2014-09-02
- 发明人: Matthias Grauert , Daniel Bischoff , Georg Dahmann , Raimund Kuelzer , Klaus Rudolf
- 申请人： Matthias Grauert , Daniel Bischoff , Georg Dahmann , Raimund Kuelzer , Klaus Rudolf
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 代理商 Michael P. Morris; Anthony P. Bottino
- 优先权： EP11190971 20111128
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/506 ; A61K31/52 ; C07D231/12 ; C07D473/34 ; C07D401/12 ; C07D403/12 ; C07D401/14 ; C07D403/14 ; A61K31/53 ; C07D409/14 ; C07D401/06 ; C07D413/14
摘要：
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.
公开/授权文献
- US20130137688A1 NOVEL COMPOUNDS 公开/授权日：2013-05-30
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