Certain aspects of an apparatus and method for orienting tissue samples for comparison may include incrementally rotating orientation of a first image by a predetermined rotation angle while maintaining orientation of a second image at a fixed angle, checking alignment of the orientation of the first image with the orientation of the second image at each predetermined rotation angle by matching a plurality of points in the first image and the second image, determining whether a predetermined rotation angle is a correct rotation angle for alignment based on a count of the plurality of points being greater than a threshold value and rotating to the next predetermined rotation angle when the count of the plurality of points is less than or equal to a threshold value.