Invention Grant
US08835385B2 FGF21 polypeptides comprising two or more mutations and uses thereof
有权
包含两个或多个突变的FGF21多肽及其用途
- Patent Title: FGF21 polypeptides comprising two or more mutations and uses thereof
- Patent Title (中): 包含两个或多个突变的FGF21多肽及其用途
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Application No.: US13426460Application Date: 2012-03-21
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Publication No.: US08835385B2Publication Date: 2014-09-16
- Inventor: Edward John Belouski , Murielle Marie Ellison , Agnes Eva Hamburger , Randy Ira Hecht , Yue-Sheng Li , Mark Leo Michaels , Jeonghoon Sun , Jing Xu
- Applicant: Edward John Belouski , Murielle Marie Ellison , Agnes Eva Hamburger , Randy Ira Hecht , Yue-Sheng Li , Mark Leo Michaels , Jeonghoon Sun , Jing Xu
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Scott N. Bernstein
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; C12N1/21 ; C12N5/10 ; C12N15/12 ; C12N15/63 ; A61K38/00
Abstract:
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, wherein the FGF 21 mutant polypeptides comprise two or more mutations, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
Public/Granted literature
- US20120177646A1 FGF21 MUTANTS AND USES THEREOF Public/Granted day:2012-07-12
Information query
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