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发明授权
US08835403B2 Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same 有权
藻酸寡糖及其衍生物以及其制备和用途

Algin oligosaccharides and the derivatives thereof as well as the manufacture and the use of the same
摘要：
The present invention provides an alginate oligosaccharide and its derivatives with the degree of polymerization ranging from 2 to 22. The alginate oligosaccharide is composed of β-D-mannuronic acid linked by 1,4 glycosidic bonds. The derivatives with the reduced terminal in position 1 of carboxyl radical can be prepared by oxidative degradation. The present invention also provides a process for preparing the alginate oligosaccharide and its derivatives, which includes the procedures that an alginate solution is reacted for 2 to 6 h in an autoclave at pH 2-6 and the temperature of 100-120° C., and pH is adjusted to 7 after the reaction is stopped, after which the resultant oligosaccharide is oxidized in the presence of an oxidant to obtain an oxidative degradation product. The alginate oligosaccharide and its derivatives of the invention can be used in the manufacture of a medicament for the prophylaxis and treatment of AD and diabetes.
摘要（中）：

本发明提供了聚合度范围为2至22的藻酸盐寡糖及其衍生物。藻酸盐寡糖由与1,4糖苷键连接的β-甘露糖醛酸组成。 羧基位置1末端的衍生物可以通过氧化降解制备。 本发明还提供了一种制备藻酸盐寡糖及其衍生物的方法，其包括藻酸盐溶液在高压釜中在pH2-6和温度为100-120℃下反应2至6小时的程序， 在反应停止后将pH调节至7，然后在氧化剂存在下氧化得到的寡糖，得到氧化降解产物。 本发明的藻酸盐寡糖及其衍生物可用于制备用于预防和治疗AD和糖尿病的药物。

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