A method includes identifying power outputs to be provided by propulsion-generating vehicles of a vehicle system for different locations along a route and calculating handling parameters of the vehicle system at the locations along the route. The handling parameters are representative of at least one of coupler forces, coupler energies, relative vehicle velocities, or natural forces exerted on the vehicle system. The method also includes determining asynchronous operational settings for the propulsion-generating vehicles at the locations. The asynchronous operational settings represent different operational settings that cause the propulsion-generating vehicles to provide at least the power outputs at the locations while changing the handling parameters of the vehicle system to designated values at the locations. The method further includes communicating the asynchronous operational settings to the propulsion-generating vehicles in order to cause the propulsion-generating vehicles to implement the asynchronous operational settings at the different locations.