A device for drilling pocket holes may include a guide carrier having a front surface urging a workpiece; at least one slant bore disposed at the guide carrier for receiving a drill bit; an anti-skid structure disposed at the front surface to secure the workpiece; a drill bit carrier reciprocally and slidably mounted on the guide carrier from a pre-drilling position to a post-drilled position toward and away from the guide carrier and a drill bit rotatably coupled and retained therein; a clamp disposed at the base and an amplifier to actuate the clamp for clamping or unclamping the workpiece by a user's power, wherein the amplifier is disposed away from the base; a quick positioning of the clamp by a braking lever; a lateral stop disposed at the clamp to set a lateral position of the pocket hole from a side face of workpiece; an adjustable end stop disposed at the guide structure or the guide carrier to adjust a pocket hole distance from an end face of workpiece; a lateral through opening disposed at the guide carrier and connected to the slant bore to remove waste material generated from workpiece drilling; a sensor disposed in a waste material remover to activate a blower when a drill motor driving the drill bit is turned on; the slant bore whose diameter is at least 7/16 inch to receive a corresponding pocket drill bit; a shank of the drill bit adapted to engage with a quick-change adapter; and a portion of pocket drill bit made of more wear-resistant material than that of the shank.