发明授权
- 专利标题： Pyrazin-2-amines useful as inhibitors of ATR kinase
- 专利标题（中）： 吡嗪-2-胺可用作ATR激酶的抑制剂
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申请号： US12642447申请日： 2009-12-18
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公开(公告)号： US08841308B2公开(公告)日： 2014-09-23
- 发明人: Jean-Damien Charrier , David Kay , Ronald Knegtel , Somhairle MacCormick , Michael O'Donnell , Joanne Pinder , Philip Michael Reaper
- 申请人： Jean-Damien Charrier , David Kay , Ronald Knegtel , Somhairle MacCormick , Michael O'Donnell , Joanne Pinder , Philip Michael Reaper
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理商 Jennifer G. Che
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965
摘要：
The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.
公开/授权文献
- US20100222318A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 公开/授权日：2010-09-02
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