发明授权
US08841336B2 Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
有权
四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
- 专利标题： Tetrazole-substituted arylamides as P2X3 and P2X2/3 antagonists
- 专利标题（中）： 四唑取代的芳酰胺如P2X3和P2X2 / 3拮抗剂
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申请号： US13240249申请日： 2011-09-22
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公开(公告)号： US08841336B2公开(公告)日： 2014-09-23
- 发明人: Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人： Li Chen , Michael Patrick Dillon , Lichun Feng , Ronald Charles Hawley , Minmin Yang
- 申请人地址： US CA Palo Alto
- 专利权人： Roche Palo Alto LLC
- 当前专利权人： Roche Palo Alto LLC
- 当前专利权人地址： US CA Palo Alto
- 代理商 Robert C. Hall
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; C07D213/12 ; C07D471/04 ; C07D401/10 ; C07D405/12 ; C07D257/04 ; C07D409/14 ; C07D401/14
摘要：
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
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