An impedance tuning and optimization technique is described wherein an impedance interface is dynamically tuned prior to applying transmit power to the circuit. A coupled signal injected into the antenna port is used to optimize the tuning state of a tuning component such that the impedance properties of the circuit are optimized prior to application of transmit power. A coupled or injected signal at an alternate frequency band can be utilized to determine tuning state or parameters at the frequency of interest by first tuning at the frequency of the coupled or injected signal and then accessing a data base containing information that relates tuning parameters across multiple frequency bands for various levels of antenna de-tuning. A time-savings is realized when the tuning circuit is optimized prior to activation or use of the transmit/receive path.