发明授权
- 专利标题: Purine derivatives
- 专利标题(中): 嘌呤衍生物
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申请号: US12489663申请日: 2009-06-23
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公开(公告)号: US08846696B2公开(公告)日: 2014-09-30
- 发明人: Peter Martin Fischer , Michael Jarman , Edward McDonald , Bernard Nutley , Florence Raynaud , Stuart Wilson , Paul Workman
- 申请人: Peter Martin Fischer , Michael Jarman , Edward McDonald , Bernard Nutley , Florence Raynaud , Stuart Wilson , Paul Workman
- 申请人地址: GB London GB London
- 专利权人: Cyclacel Limited,Cancer Research Technology Limited
- 当前专利权人: Cyclacel Limited,Cancer Research Technology Limited
- 当前专利权人地址: GB London GB London
- 代理机构: Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Cynthia L. Kanik
- 优先权: GB0219054.4 20020815
- 主分类号: A61K31/52
- IPC分类号: A61K31/52 ; C07D473/16
摘要:
The present invention relates to compounds of formula 1 or pharmaceutically acceptable salts thereof, wherein one of R1 and R2 is methyl, ethyl or isopropyl, and the other is H; R3 and R4 are each independently H, branched or unbranched C1-C6 alkyl, or aryl, and wherein at least one of R3 and R4 is other than H; R5 is a branched or unbranched C1-C5 alkyl group or a C1-C6 cycloalkyl group, each of which may be optionally substituted with one or more OH groups; R6, R7, R8 and R9 are each independently H, halogen, NO2, OH, OMe, CN, NH2, COOH, CONH2, or SO2NH2. A further aspect of the invention relates to pharmaceutical compositions comprising compounds of formula 1, and the use of said compounds in treating proliferative disorders, viral disorders, stroke, alopecia, CNS disorders, neurodegenerative disorders, or diabetes.
公开/授权文献
- US20090325983A1 NEW PURINE DERIVATIVES 公开/授权日:2009-12-31
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