The present disclosure provides a mini-scale microfluidic valve including a valve housing disposed at a fluid dispensing orifice of a mini-scale microfluidic system dispensing nozzle. The valve housing comprises a base member having a base member orifice that aligns with the fluid dispensing orifice to provide a fluid dispensing pathway through which a system-fluid is dispensed from the system dispensing nozzle to an external ambient environment. The housing additionally comprises an open valve channel exposed to the external ambient environment and intersecting the fluid dispensing pathway. The valve further includes a liquid-film movably disposed within the open valve channel such that the liquid-film is exposed to the external ambient environment. The liquid-film comprises a substantially non-volatile, immiscible liquid, and a valve control subsystem structured and operable to control movement of the liquid-film within the open valve channel to selectively cover and uncover the base member orifice.