A pumping system includes a submersible high speed electric motor operable to rotate a drive shaft; a high speed pump rotationally connected to the drive shaft and including a rotor having one or more helicoidal vanes; an isolation device operable to expand into engagement with a production tubing string, thereby fluidly isolating an inlet of the pump from an outlet of the pump and rotationally connecting the motor and the pump to the casing string; a cable having two or less conductors and a strength sufficient to support the motor, the pump, the isolation device, and a power conversion module (PCM); and the PCM operable to receive a DC power signal from the cable, and supply a second power signal to the motor.