A fluidic compression connection includes a first sealing device having a fluid inlet at an entry opening and a first mating surface at an exit opening end; a second sealing device having an interchangeable plug-and-play consumable insert, a second mating surface at the entry opening end and a third mating surface at the exit opening end; a third sealing device having a fluid outlet at the exit opening and a fourth mating surface at the entry opening end; a mechanical support; and a drive force mechanism, wherein the first mating surface opposes the second mating surface and the third mating surface opposes the fourth mating surface, and wherein the drive force mechanism is configured to apply a substantially axial drive force opposed by the mechanical support, to compress the first, second, and third sealing devices and create a leak-resistant seal in the connection between the sealing devices.