Invention Grant
- Patent Title: Process for production of surface-coated inorganic particles
- Patent Title (中): 表面被覆无机粒子的制造方法
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Application No.: US12670807Application Date: 2008-07-25
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Publication No.: US08852555B2Publication Date: 2014-10-07
- Inventor: Hiroshi Handa , Mamoru Hatakeyama , Masanori Abe , Satoshi Sakamoto , Yuka Masaike , Kosuke Nishio , Yoshinori Kita , Hiroshi Kishi
- Applicant: Hiroshi Handa , Mamoru Hatakeyama , Masanori Abe , Satoshi Sakamoto , Yuka Masaike , Kosuke Nishio , Yoshinori Kita , Hiroshi Kishi
- Applicant Address: JP Tokyo
- Assignee: Tokyo Institute of Technology
- Current Assignee: Tokyo Institute of Technology
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JPP2007-194233 20070726
- International Application: PCT/JP2008/063361 WO 20080725
- International Announcement: WO2009/014201 WO 20090129
- Main IPC: A61K49/00
- IPC: A61K49/00 ; C09C3/08 ; B22F1/00 ; B82Y30/00 ; A61K49/18 ; C09C1/24 ; C09C3/10 ; G01N33/543 ; B82Y25/00 ; H01F1/00 ; C09C3/12 ; A61K41/00

Abstract:
Nano-sized inorganic particles having uniform particle sizes and precisely controlled particle diameters have already been produced by synthesis in an organic solvent, but these nano-sized inorganic particles are hindered from dispersing in a polar solvent because of the adsorption of a long-chain fatty acid on the surfaces of the particles. Further, it was difficult to form nano-sized inorganic particles dispersible in a polar solvent by replacing the long-chain fatty acid coats. According to the invention, various surface-coated inorganic particles dispersible in polar solvents can be produced from fatty acid-coated inorganic particles by adding a temporary coating substance such as thiomalic acid to a nonpolar solvent containing fatty acid-coated inorganic particles dispersed therein to replace the fatty acid coats by the temporary coating substance, dispersing the inorganic particles coated with the temporary coating substance in a polar solvent, and then adding a coating substance dispersible in a polar solvent, e.g., citric acid to the obtained dispersion to replace the temporary coating substance coats covering the inorganic particles by the coating substance dispersible in a polar solvent.
Public/Granted literature
- US20100254908A1 PROCESS FOR PRODUCTION OF SURFACE-COATED INORGANIC PARTICLES Public/Granted day:2010-10-07
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