Invention Grant
- Patent Title: Cardiac muscle regeneration using mesenchymal stem cells
- Patent Title (中): 使用间充质干细胞进行心肌再生
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Application No.: US13369917Application Date: 2012-02-09
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Publication No.: US08852571B2Publication Date: 2014-10-07
- Inventor: Mark F. Pittenger , Stephen L. Gordon , Alastair Morgan Mackay , Bradley J. Martin
- Applicant: Mark F. Pittenger , Stephen L. Gordon , Alastair Morgan Mackay , Bradley J. Martin
- Applicant Address: CH
- Assignee: Mesoblast International Sarl
- Current Assignee: Mesoblast International Sarl
- Current Assignee Address: CH
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/85 ; C12N5/077 ; C12N5/0775 ; A61K35/12
Abstract:
Disclosed is a method for producing cardiomyocytes in vivo by administering to the heart of an individual a cardiomyocyte producing amount of mesenchymal stem cells. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid. The cells can be genetically modified to enhance myocardial differentiation and integration. Also disclosed is a method for replacing cells ex vivo in a heart valve for implantation.
Public/Granted literature
- US20120141437A1 Cardiac Muscle Regeneration Using Mesenchymal Stem Cells Public/Granted day:2012-06-07
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