Invention Grant
- Patent Title: Modified sodium iodide symporter proteins and uses thereof
- Patent Title (中): 改性碘化钠同向转运蛋白及其用途
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Application No.: US12901096Application Date: 2010-10-08
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Publication No.: US08852576B2Publication Date: 2014-10-07
- Inventor: Tin-Yun Ho , Chien-Yun Hsiang , Shih-Lu Wu , Ji-An Liang , Chia-Cheng Li , Hsin-Yi Lo
- Applicant: Tin-Yun Ho , Chien-Yun Hsiang , Shih-Lu Wu , Ji-An Liang , Chia-Cheng Li , Hsin-Yi Lo
- Applicant Address: TW Taichung
- Assignee: China Medical University
- Current Assignee: China Medical University
- Current Assignee Address: TW Taichung
- Agency: Andrews Kurth LLP
- Agent Ping Wang
- Priority: TW99124881A 20100728
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A61K48/00 ; C12N5/00 ; C12N15/00 ; C07K14/705
Abstract:
A modified sodium iodide symporter (NIS) protein is provided. The modified NIS protein comprises an amino acid sequence of SEQ ID NO.1 with the proviso that at least one amino acid residue within SEQ ID NO. 1 is changed. The modified NIS protein has an enhanced transport function, and the expression of the modified NIS protein in the cells results in higher intracellular levels of a substrate of a NIS protein than does the expression of the same amount of a wild-type NIS protein.
Public/Granted literature
- US20120027676A1 MODIFIED SODIUM IODIDE SYMPORTER PROTEINS AND USES THEREOF Public/Granted day:2012-02-02
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