Invention Grant
- Patent Title: Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof
- Patent Title (中): 能够结合和中和乙型流感病毒的人结合分子及其用途
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Application No.: US14051365Application Date: 2013-10-10
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Publication No.: US08852595B2Publication Date: 2014-10-07
- Inventor: Ronald Vogels , Theodorus H. J. Kwaks
- Applicant: Crucell Holland B.V.
- Applicant Address: NL Leiden
- Assignee: Crucell Holland B.V.
- Current Assignee: Crucell Holland B.V.
- Current Assignee Address: NL Leiden
- Agency: TraskBritt, P.C.
- Priority: EP12158525 20120308
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K39/395 ; A61K39/42 ; A61K39/38 ; A61K39/145 ; C12Q1/70 ; C07K16/10 ; G01N33/569 ; A61K39/00

Abstract:
Described are binding molecules, such as human monoclonal antibodies, that bind to hemagglutinin of influenza B viruses, and have a broad neutralizing activity against such influenza viruses. These binding molecules do not bind to hemagglutinin of influenza A viruses. Further provided are nucleic acid molecules encoding the binding molecules, and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis of, prophylaxis against, and/or treatment of influenza B virus infections.
Public/Granted literature
- US20140065165A1 HUMAN BINDING MOLECULES CAPABLE OF BINDING TO AND NEUTRALIZING INFLUENZA B VIRUSES AND USES THEREOF Public/Granted day:2014-03-06
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