Invention Grant
US08852597B2 Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties
有权
具有减弱的FcR结合和/或补体结合性质的抗CD154抗体
- Patent Title: Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties
- Patent Title (中): 具有减弱的FcR结合和/或补体结合性质的抗CD154抗体
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Application No.: US13439186Application Date: 2012-04-04
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Publication No.: US08852597B2Publication Date: 2014-10-07
- Inventor: Randolph J. Noelle
- Applicant: Randolph J. Noelle
- Applicant Address: US NH Hanover
- Assignee: The Trustees of Dartmouth College
- Current Assignee: The Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: LeClairRyan, a professional corporation
- Agent Robin L. Teskin
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/46 ; A61K39/00
Abstract:
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity, inflammation and allergic disorders is disclosed herein.
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