Invention Grant
- Patent Title: Puumala virus full-length M segment-based DNA vaccines
- Patent Title (中): Puumala病毒全长M段DNA疫苗
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Application No.: US13444828Application Date: 2012-04-11
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Publication No.: US08852598B2Publication Date: 2014-10-07
- Inventor: Jay Hooper
- Applicant: Jay Hooper
- Assignee: United States of America as represented by the Secretary of the Army
- Current Assignee: United States of America as represented by the Secretary of the Army
- Agent Elizabeth Arwine
- Main IPC: A61K39/42
- IPC: A61K39/42 ; A61K39/12
Abstract:
The invention contemplates a new synthetic, codon-optimized Puumala virus (PUUV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The PUUV ORF was cloned into a plasmid to form the first stable PUUV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a molecular vaccine system, and is useful to protect mammals against infection with Puumala virus.
Public/Granted literature
- US20130273170A1 PUUMALA VIRUS FULL-LENGTH M SEGMENT-BASED DNA VACCINES Public/Granted day:2013-10-17
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