Invention Grant
US08852600B2 Codon-optimized DNA molecules encoding the receptor binding domains of Clostridium difficile toxins A and B, and methods of use thereof
有权
密码子优化的编码艰难梭菌毒素A和B的受体结合结构域的DNA分子及其使用方法
- Patent Title: Codon-optimized DNA molecules encoding the receptor binding domains of Clostridium difficile toxins A and B, and methods of use thereof
- Patent Title (中): 密码子优化的编码艰难梭菌毒素A和B的受体结合结构域的DNA分子及其使用方法
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Application No.: US12308150Application Date: 2007-06-07
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Publication No.: US08852600B2Publication Date: 2014-10-07
- Inventor: David F. Gardiner , Yaoxing Huang
- Applicant: David F. Gardiner , Yaoxing Huang
- Applicant Address: US NY New York US NY Ithaca
- Assignee: The Rockefeller University,Cornell University
- Current Assignee: The Rockefeller University,Cornell University
- Current Assignee Address: US NY New York US NY Ithaca
- Agency: Hoffmann & Baron, LLP
- International Application: PCT/US2007/013535 WO 20070607
- International Announcement: WO2007/146139 WO 20071221
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/38 ; A61K39/08 ; C12N15/00 ; C12N1/20 ; C07H21/04 ; C07K14/33
Abstract:
In one aspect, the invention provides a DNA molecule. The DNA molecule includes a nucleotide sequence that encodes the receptor-binding domain of Clostridium difficile toxin A or toxin B in which at least about 10% of the in-frame codons for each amino acid residue has a higher percentage use in the human genome than the corresponding in-frame codons of C. difficile toxin A or toxin B having a known sequence. Methods for generating antibodies to Clostridium difficile toxin A or toxin B, methods for reducing the risk of a C. difficile infection, and methods for treating a C. difficile are also provided.
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