Invention Grant
- Patent Title: Capsular polysaccharide solubilisation and combination vaccines
- Patent Title (中): 荚膜多糖增溶和联合疫苗
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Application No.: US12353409Application Date: 2009-01-14
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Publication No.: US08852606B2Publication Date: 2014-10-07
- Inventor: Paolo Costantino
- Applicant: Paolo Costantino
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Helen Lee; Otis Littlefield
- Priority: GB0115176.0 20010620
- Main IPC: A61K39/385
- IPC: A61K39/385 ; A61K45/00 ; A61K47/00 ; A61K39/00 ; A61K39/095 ; A61K39/102 ; A61K39/09 ; A61K39/08 ; C09F1/02 ; A23J1/00 ; C07K1/00 ; C07K14/00 ; C07K16/00 ; C07K17/00 ; C07H1/06 ; C07H1/08

Abstract:
Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilization of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide:MenC saccharide is >1.
Public/Granted literature
- US20090130140A1 Capsular Polysaccharide Solubilisation and Combination Vaccines Public/Granted day:2009-05-21
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