Invention Grant
- Patent Title: Composition for detecting the response of rectal adenocarcinomas to radiochemotherapy
- Patent Title (中): 用于检测直肠腺癌对放射化疗的反应的组成
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Application No.: US10585725Application Date: 2005-01-12
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Publication No.: US08852861B2Publication Date: 2014-10-07
- Inventor: Thomas Ried , Michael J. Difilippantonio , Bijan-Michael Ghadimi , Marian Grade , Heinz Becker , Torsten Liersch
- Applicant: Thomas Ried , Michael J. Difilippantonio , Bijan-Michael Ghadimi , Marian Grade , Heinz Becker , Torsten Liersch
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US DC Washington
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless
- International Application: PCT/US2005/000891 WO 20050112
- International Announcement: WO2005/073411 WO 20050811
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/01
Abstract:
A cDNA array (9984 genes) was used for expression profiling in rectal adenocarcinoma. The expression data were correlated to responsiveness to chemotherapy followed by radiotherapy. A set of 54 genes was found that were differentially expressed in responders vs. non-responders. The genes may be used as prognostic markers for determining whether a rectal adenocarcinoma is responsive to radiochemotherapy.
Public/Granted literature
- US20080020373A1 Composition for Detecting the Response of Rectal Adenocarcinomas to Radiochemotherapy Public/Granted day:2008-01-24
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