Invention Grant
US08852871B2 Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE)
有权
用于治疗系统性红斑狼疮（SLE）的人源化抗IL-10抗体
- Patent Title: Humanized anti-IL-10 antibodies for the treatment of systemic lupus erythematosus (SLE)
- Patent Title (中): 用于治疗系统性红斑狼疮（SLE）的人源化抗IL-10抗体
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Application No.: US13512780Application Date: 2010-11-30
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Publication No.: US08852871B2Publication Date: 2014-10-07
- Inventor: Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
- Applicant: Frank Osterroth , Christoph Uherek , Christoph Bruecher , Peter Röttgen , Benjamin Daelken , André Engling , Chantal Zuber , Niklas Czeloth , Andrea Wartenberg-Demand , Marcus Gutscher , Judith Wessels-Kranz
- Applicant Address: DE Dreieich
- Assignee: Biotest AG
- Current Assignee: Biotest AG
- Current Assignee Address: DE Dreieich
- Agency: LeClairRyan, a professional corporation
- Agent Robin L. Teskin
- Priority: GB0920933.9 20091130; GB0920940.4 20091130; GB0920942.0 20091130
- International Application: PCT/EP2010/068562 WO 20101130
- International Announcement: WO2011/064398 WO 20110603
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/577 ; G01N33/58 ; C07K16/00 ; C07K16/24 ; A61K39/00
Abstract:
Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (Th-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof.
Public/Granted literature
- US20120321618A1 HUMANIZED ANTI-IL 10 ANTIBODIES FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) Public/Granted day:2012-12-20
Information query
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