Invention Grant
- Patent Title: Ketoreductase polypeptides for the reduction of acetophenones
- Patent Title (中): 用于还原苯乙酮的酮还原酶多肽
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Application No.: US13970284Application Date: 2013-08-19
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Publication No.: US08852909B2Publication Date: 2014-10-07
- Inventor: Jack Liang , Stephane J. Jenne , Emily Mundorff , Charlene Ching , John M. Gruber , Anke Krebber , Gjalt W. Huisman
- Applicant: Codexis, Inc.
- Applicant Address: US CA Redwood City
- Assignee: Codexis, Inc.
- Current Assignee: Codexis, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Codexis, Inc.
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C07K14/00 ; C12N9/04 ; C12P7/22 ; C12Q1/26 ; C12P21/00
Abstract:
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
Public/Granted literature
- US20130344552A1 KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES Public/Granted day:2013-12-26
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