Invention Grant
US08852928B2 LexA-based chemical-inducible gene expression system for use in transgenic animals
有权
基于LexA的化学诱导型基因表达系统用于转基因动物
- Patent Title: LexA-based chemical-inducible gene expression system for use in transgenic animals
- Patent Title (中): 基于LexA的化学诱导型基因表达系统用于转基因动物
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Application No.: US12663323Application Date: 2008-07-02
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Publication No.: US08852928B2Publication Date: 2014-10-07
- Inventor: Alexander Emelyanov , Sergey Parinov , Nam-Hai Chua
- Applicant: Alexander Emelyanov , Sergey Parinov , Nam-Hai Chua
- Applicant Address: SG Singapore
- Assignee: Temasek Life Sciences Laboratory Limited
- Current Assignee: Temasek Life Sciences Laboratory Limited
- Current Assignee Address: SG Singapore
- Agency: Rothwell, Figg, Ernst & Manbeck P.C.
- International Application: PCT/SG2008/000237 WO 20080702
- International Announcement: WO2009/008837 WO 20090115
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C07H21/02 ; C07H21/04 ; C12N15/85 ; A01K67/027 ; A01K67/00
Abstract:
The present invention relates generally to chemical-inducible system and to methods of use in transgenic animals. More specifically, the present invention relates to a chimeric transcription factor that binds to a ligand and functions in ligand-dependent manner to induce expression of genes of interest under the control of a synthetic operator-promoter sequence. The expression of genes of interest can be tightly controlled by adding or removing the ligand.
Public/Granted literature
- US20100269182A1 LEXA-BASED CHEMICAL-INDUCIBLE GENE EXPRESSION SYSTEM FOR USE IN TRANSGENIC ANIMALS Public/Granted day:2010-10-21
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