Invention Grant
US08852931B2 Identification of a JAK2 mutation involved in vaquez polyglobulia
有权
鉴定涉及vaquez多囊性的JAK2突变
- Patent Title: Identification of a JAK2 mutation involved in vaquez polyglobulia
- Patent Title (中): 鉴定涉及vaquez多囊性的JAK2突变
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Application No.: US13768709Application Date: 2013-02-15
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Publication No.: US08852931B2Publication Date: 2014-10-07
- Inventor: William Vainchenker , Valérie Ugo , James Chloe , Jean-Pierre Le Couedic , Nicole Casadevall
- Applicant: Assistance Publique—Hopitaux de Paris , IGR&D SA , Institut National de la Sante et de la Recherche Medicale (INSERM) , Institut Gustave-Roussy , Universite de Versailles—St Quentin en Yvelines , Universite Paris-Sud
- Applicant Address: FR Paris FR Paris FR Villejuif FR Versailles FR Orsay
- Assignee: Assitance Publique—Hopitaux de Paris,Institut National de la Sante et de la Recherche Medicale (INSERM),Institut Gustave-Roussy,Universite de Versailles—St Quentin en Yvelines,Universite Paris-Sud
- Current Assignee: Assitance Publique—Hopitaux de Paris,Institut National de la Sante et de la Recherche Medicale (INSERM),Institut Gustave-Roussy,Universite de Versailles—St Quentin en Yvelines,Universite Paris-Sud
- Current Assignee Address: FR Paris FR Paris FR Villejuif FR Versailles FR Orsay
- Agency: Foley & Lardner LLP
- Priority: FR0411480 20041027
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12N15/63 ; C07H21/04 ; G01N33/574 ; C12Q1/68
Abstract:
The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
Public/Granted literature
- US20130189683A1 IDENTIFICATION OF A JAK2 MUTATION INVOLVED IN VAQUEZ POLYGLOBULIA Public/Granted day:2013-07-25
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