Invention Grant
- Patent Title: Lithium stimulation of cord blood stem cell proliferation and growth factor production
- Patent Title (中): 锂刺激脐血干细胞增殖和生长因子的产生
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Application No.: US12513331Application Date: 2007-10-31
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Publication No.: US08852938B2Publication Date: 2014-10-07
- Inventor: DongMing Sun , Wise Young
- Applicant: DongMing Sun , Wise Young
- Applicant Address: US NJ New Brunswick
- Assignee: Rutgers, The State University of New Jersey
- Current Assignee: Rutgers, The State University of New Jersey
- Current Assignee Address: US NJ New Brunswick
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2007/083210 WO 20071031
- International Announcement: WO2008/055224 WO 20080508
- Main IPC: C12N5/02
- IPC: C12N5/02 ; C12N5/0789 ; A61K35/50
Abstract:
The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture system comprising a lithium salt. The present invention also provides in vivo methods for enhancing the survival and growth of transplanted cord blood stem cells by treating the cells with a lithium salt prior to transplantation. In vivo methods for reducing rejection of transplanted cord blood stem cells by administering a lithium salt after transplantation are also provided.
Public/Granted literature
- US20100189696A1 LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION Public/Granted day:2010-07-29
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