Invention Grant
- Patent Title: GLP-1, exendin-4, peptide analogs and uses thereof
- Patent Title (中): GLP-1，毒蜥外泌肽-4，肽类似物及其用途
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Application No.: US13594313Application Date: 2012-08-24
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Publication No.: US08853160B2Publication Date: 2014-10-07
- Inventor: Nigel H. Greig , Josephine M. Egan , Maire Doyle , Harold W. Holloway , Tracy Perry
- Applicant: Nigel H. Greig , Josephine M. Egan , Maire Doyle , Harold W. Holloway , Tracy Perry
- Applicant Address: US MD Rockville
- Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
- Current Assignee Address: US MD Rockville
- Agency: Edwards Wildman Palmer LLP
- Agent Peter F. Corless
- Main IPC: A61K38/26
- IPC: A61K38/26 ; A61P3/10 ; A61P7/12 ; C07K14/605 ; C07K14/575 ; A61K38/00 ; A61K38/22
Abstract:
The invention relates to novel polypeptide analogs of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogs thereof for neuroprotective and neurotrophic effects.
Public/Granted literature
- US20120329715A1 GLP-1, EXENDIN-4, PEPTIDE ANALOGS AND USES THEREOF Public/Granted day:2012-12-27
Information query
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