Invention Grant
- Patent Title: Methods for increasing vascular density and maintaining viability of microvascular endothelial cells using trk receptor ligands
- Patent Title (中): 使用trk受体配体增加血管密度和维持微血管内皮细胞活力的方法
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Application No.: US12785183Application Date: 2010-05-21
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Publication No.: US08853163B2Publication Date: 2014-10-07
- Inventor: Barbara L. Hempstead , Rosemary Kraemer , Shahin Rafii , Phi Wiegn , Michael J. Donovan
- Applicant: Barbara L. Hempstead , Rosemary Kraemer , Shahin Rafii , Phi Wiegn , Michael J. Donovan
- Applicant Address: US NY Ithaca US MA Boston
- Assignee: Cornell Research Foundation, Inc.,Children's Medical Center Corporation
- Current Assignee: Cornell Research Foundation, Inc.,Children's Medical Center Corporation
- Current Assignee Address: US NY Ithaca US MA Boston
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/475 ; A61K31/7088 ; A61K38/17 ; C12N15/85 ; A61K48/00
Abstract:
The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.
Public/Granted literature
- US20100227823A1 METHODS FOR REGULATING ANGIOGENESIS AND VASCULAR INTEGRITY USING TRK RECEPTOR LIGANDS Public/Granted day:2010-09-09
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