Invention Grant
- Patent Title: Short-chain cationic polyamino acid and use thereof
- Patent Title (中): 短链阳离子聚氨基酸及其用途
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Application No.: US13258663Application Date: 2011-02-23
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Publication No.: US08853167B2Publication Date: 2014-10-07
- Inventor: Yasuki Kato , Atsushi Ishii , Naoya Shibata , Tatsuyuki Hayashi , Kazunori Kataoka , Kanjiro Miyata , Nobuhiro Nishiyama
- Applicant: Yasuki Kato , Atsushi Ishii , Naoya Shibata , Tatsuyuki Hayashi , Kazunori Kataoka , Kanjiro Miyata , Nobuhiro Nishiyama
- Applicant Address: JP Kashiwa-Shi
- Assignee: NanoCarrier Co., Ltd.
- Current Assignee: NanoCarrier Co., Ltd.
- Current Assignee Address: JP Kashiwa-Shi
- Agency: J-Tek Law PLLC
- Agent Jeffrey D. Tekanic
- Priority: JP2010-037014 20100223
- International Application: PCT/JP2011/053917 WO 20110223
- International Announcement: WO2011/105402 WO 20110901
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C08G69/10 ; C12N15/11

Abstract:
The present invention provides a cationic polyamino acid suitable for a carrier that can form a stable complex with a nucleic acid under a physiological condition and release the nucleic acid in cells suitably. The cationic polyamino acid can associate with a nucleic acid and includes a cationic amino acid residue having a cationic group in a side chain and a hydrophobic amino acid residue having a hydrophobic group in a side chain. The cationic polyamino acid includes 1 to 20 units of the cationic amino acid residue and is represented by the following formula (1). The meaning of each symbol in the formula is as shown in the description.
Public/Granted literature
- US20120149649A1 SHORT-CHAIN CATIONIC POLYAMINO ACID AND USE THEREOF Public/Granted day:2012-06-14
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